Effects of Chronic Antihypertensive Therapy on Clinical Outcomes in Septic Shock

Rush

Status: Completed

Conditions: Atrial Fibrillation; Septic Shock

Study type: Observational

Funder types: Other

Identifiers

NCT02876341

16081002

Details and patient eligibility

About

Retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock.

Full description

This will be a retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock. The two cohorts will be septic shock patients that were: 1) not on either a chronic β-blocker or angiotensin-converting-enzyme inhibitor (ACE inhibitor) or 2) on a chronic β-blocker, on chronic ACE-Inhibitor, or on both chronic β-blocker and ACE-inhibitor

Enrollment: 133 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients 18 years of age or older
• Diagnosis of septic shock requiring vasopressor therapy (norepinephrine, epinephrine, phenylephrine, dopamine, or vasopressin)
• Admitted to the medical intensive care unit (MICU) at Rush University Medical Center (RUMC)
• Time frame: 01/01/2012 to 07/1/2016

Exclusion criteria

• Pregnant patients
• Transfer from outside hospital on vasopressors
• Admitted to MICU in cardiopulmonary arrest
• Prior arrest within 24 hours of admission to RUMC

Trial design

133 participants in 2 patient groups

No chronic antihypertensives

Description:

Not on either a chronic β-blocker or ACE-Inhibitor

Chronic antihypertensives

Description:

On a chronic β-blocker, on chronic ACE-Inhibitor, or on both chronic β-blocker and ACE-inhibitor