Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses to Exercise in Obese Males

California Baptist University

Status: Completed

Conditions: Obesity Adult Onset

Treatments: Dietary Supplement: Grape Seed Extract

Study type: Interventional

Funder types: Other

Identifiers

NCT04465110

109-1819-EXP

Details and patient eligibility

About

It was demonstrated that acute dietary supplementation with GSE reduced arterial blood pressure via reduction in Q in obese individuals. However, no studies have investigated the chronic effects of dietary GSE supplementation on hemodynamic responses during exercise. Given the fact that obesity is associated with an impaired function of eNOS, the effect of chronic dietary GSE supplementation on abnormal blood pressure response to exercise and aortic stiffness (AoS) needs be elucidated. Thus, it is hypothesized that GSE decreases systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), Q, and aortic stiffness at rest and during exercise. This study would determine that this supplementation may be used as a non-pharmacological intervention to prevent incident hypertension and cardiovascular events during exercise via enhanced endothelial function.

Full description

We investigated whether elevated blood pressure and aortic stiffness (AoS) characterized in obese and overweight males (N=10) are reduced following chronic GSE supplementation during exercise. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total vascular conductance (TVC), and AoS to two submaximal cycling exercises (40% and 60% VO2peak) were compared 7 days after ingestion of GSE or placebo (PL) within an one week washout period. Compared with PL, GSE supplementation significantly decreased MAP at rest, 40%, and 60% workloads. AoS was significantly reduced at rest. Q tended to be decreased, but there was no significant difference. GSE had no effect on HR, TVC, and SV. Our study indicates that chronic supplementation with GSE reduces arterial pressure at rest and during exercise primarily via the combined reduction of AoS and Q. Thus, GSE can be a dietary supplement to treat augmented blood pressure responses in obese and overweight males at rest and during exercise.

Enrollment: 10 patients

Sex: Male

Ages: 18 to 29 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Overweight: 25-29.9 kg/m2
• Obese: > 30 kg/m2
• Waist circumference: > 90 cm

Exclusion criteria

• Antihypertensive medication
• Major systemic disease (cancer)
• Musculoskeletal diseases
• Cardiovascular diseases or symptoms including chest pain
• Myocardial infarction
• Arrhythmias
• Heart failure

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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10 participants in 2 patient groups, including a placebo group

GSE group

Experimental group

Description:

Subjects took a single dose of 600 mg GSE in capsule form through ingestion 7 days

Treatment:

Dietary Supplement: Grape Seed Extract

Placebo group

Placebo Comparator group

Description:

Subjects took a single dose of 600 mg starch in capsule form through ingestion 7 days

Treatment:

Dietary Supplement: Grape Seed Extract