Effects of Chronic Intake of Cannabis on Contrast Sensitivity

University Hospital, Strasbourg, France

Status: Completed

Conditions: Cannabis Dependence

Treatments: Other: contrast sensitivity tests; Other: electroretinogram

Study type: Interventional

Funder types: Other

Identifiers

NCT01793961

2012-A00991-42 (Other Identifier)

5331

Details and patient eligibility

About

Rates of driving under the influence of cannabis have risen in recent years. Cannabis is involved in 1/3 of motor vehicle collisions. The chronic use of cannabis is known to affect dopaminergic regulation and may thus impair contrast sensitivity. In turn, contrast sensitivity disorders could originate difficulties to anticipate and avoid collision with objects, especially when objects are in movement. The investigators goal is to examine the effects of a chronic intake of cannabis on contrast sensitivity. The observed values will be compared to standard references. In addition, since smoking cannabis is always associated with tobacco, the investigators will control the effects of tobacco on contrast sensitivity.

In this study, the investigators will include 36 cannabis addicts, 36 tobacco addicts and 36 no smokers. The investigators will present gratings with different spatial frequencies and the investigators will determine contrast thresholds for static and dynamic (moving) gratings. The investigators predict that cannabis addicts will present abnormal contrast sensitivity especially in case of dynamic presentation of gradings.

Enrollment: 95 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

"Cannabis" Arm

• patient addicted to cannabis
• Positive CAST test result
• Urine tested positive for cannabis metabolites

"Tobacco" Arm

• positive Fagerström test result
• No cannabis intake in the last year before inclusion
• No previous history of cannabis use

"Healthy Volunteers"

• No tobacco or cannabis intake in the last year before inclusion
• No history of addictive disorders

Exclusion criteria

• addiction to other substances than cannabis or tobacco
• benzodiazepine treatment
• patient with history of benzodiazepine treatment
• patient with history of general anesthesia in the last 3 months before inclusion
• patient with history of head trauma
• Pregnant woman
• breast feeding woman
• Adults under supervision or guardianship

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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95 participants in 3 patient groups

"Cannabis" Arm

Other group

Description:

patient addicted to cannabis

Treatment:

Other: contrast sensitivity tests

Other: electroretinogram

"Tobacco" Arm

Other group

Description:

patient addicted to tobacco

Treatment:

Other: contrast sensitivity tests

Other: electroretinogram

"Healthy volunteers"

Other group

Description:

no smokers

Treatment:

Other: contrast sensitivity tests

Other: electroretinogram