Effects of Chronic Smoking on Circulating Endothelial and Platelet-derived Microparticle

Kurume University

Status and phase: Completed; Early Phase 1

Conditions: Atherosclerosis

Treatments: Behavioral: smoking cessation

Study type: Interventional

Funder types: Other

Identifiers

NCT00795249

KurumeU-08061

Details and patient eligibility

About

The investigators hypothesized that circulating EMP is a useful surrogate marker of early stage of endothelial damage. To determine the effects of chronic smoking on circulating EMP, from healthy volunteers who have habit of chronic smoking, peripheral blood is drawn at the time of flow-mediated dilatation (FMD) examination. Spot urine is also collected. Circulating EMPs are counted using flow-cytometry. After 2-week smoking cessation, the measurements were repeated.

Enrollment: 100 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy individuals who have no coronary risk factors

Exclusion criteria

• hypertension
• dyslipidemia
• chronic kidney disease
• liver dysfunction
• obesity (BMI>25.0)
• cerebrovascular disease
• other severe systemic diseases (cancer, inflammatory diseases, etc)

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

smoker

Experimental group

Description:

Individuals who have a habit of chronic smoking without any coronary risk factors

Treatment:

Behavioral: smoking cessation

non-smoker

No Intervention group

Description:

the age-matched healthy volunteers