Effects of Circadian Rhythm on Glycemic Regulation During Continuous Moderate Exercise and Intense Intermittent Disease in Adolescents Living With Type 1 Diabetes (CHRONODIAB1)

Lille University

Status: Enrolling

Conditions: Type 1 Diabetes

Treatments: Other: physical test

Study type: Interventional

Funder types: Other

Identifiers

NCT06803446

D2024-05

Details and patient eligibility

About

Interventional research with minimal risks and constraints on the effects of circadian rhythm on glycemic regulation during intense moderate, continuous and intermittent exercise in adolescents living with type 1 diabetes

Full description

Single-center, randomized, controlled study in adolescents living with type 1 diabetes. This study aims to evaluate the effect of exercise timing (morning vs. afternoon) and exercise type (continuous vs. intermittent) on blood glucose levels during and after exercise, as well as to assess the effect of exercise timing (morning vs. afternoon) and type of exercise (continuous vs. intermittent) on blood glucose during and after exercise

Enrollment: 18 estimated patients

Sex: All

Ages: 10 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children and adolescents aged 10 to 16;
• Living with type 1 diabetes for at least 1 year with HbA1c less than or equal to 12%;
• Socially insured ;
• Having given their written consent to participate in the research, as well as that of their legal guardians;
• Willing to comply with all research procedures and duration.

Exclusion criteria

• Clinically significant microvascular complications: nephropathy (estimated glomerular filtration rate less than 40 ml/min), neuropathy or severe proliferative retinopathy as assessed by the investigator;
• Recent acute macrovascular event (< 3 months), e.g. acute coronary syndrome or cardiac surgery;
• Abnormal blood picture and/or anemia;
• Current pregnancy;
• Other serious medical condition likely to interfere with study participation or ability to complete exercise periods in the judgment of the investigator (e.g., orthopedic limitation);
• Inability to receive informed information;
• Inability to participate in the entire study;
• Lack of social security coverage;
• Refusal to sign the consent form.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

---

18 participants in 4 patient groups

Continuous - morning

Experimental group

Description:

Continuous exercise on ergocycle in the morning

Continuous - afternoon

Experimental group

Description:

Continuous exercise on ergocycle in the afternoon

Treatment:

Other: physical test

Intermittent - morning

Experimental group

Description:

Intermittent exercise on ergocycle in the morning

Intermittent - afternoon

Experimental group

Description:

Intermittent exercice on ergocycle in the afternoon

Treatment:

Other: physical test