Effects of Cisatracurium on Sccinylcholine-induced Fasciculations

Zhuan Zhang

Status and phase: Completed; Phase 3

Conditions: Fasciculations

Treatments: Drug: Cisatracurium

Study type: Interventional

Funder types: Other

Identifiers

NCT02502032

ZZ0716

Details and patient eligibility

About

To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations.

Full description

Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before cisatracurium pretreatments, at intubating time, and 5 min after intubation were recorded.

Enrollment: 87 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Standards Association (ASA) physical status I or II patients scheduled for elective laparoscopic cholecystectomies with tracheal intubation requiring general anesthesia;
• 20 - 65 years old;
• Without acid-base imbalance and electrolyte disturbance;
• With normal hepatic and renal function.

Exclusion criteria

• Patients with the contraindications associated with succinylcholine or cisatracurium;
• Patients taking drugs known to alter the action of neuromuscular blockers;
• Patients with a body mass index exceeding 30

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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87 participants in 3 patient groups

Cisatracurium 0.005 mg/kg

Experimental group

Description:

The group received pretreatment of cisatracurium 0.005 mg/kg.

Treatment:

Drug: Cisatracurium

Cisatracurium 0.01 mg/kg

Experimental group

Description:

The group received pretreatment of cisatracurium 0.01 mg/kg.

Treatment:

Drug: Cisatracurium

Cisatracurium 0.02 mg/kg

Experimental group

Description:

The group received pretreatment of cisatracurium 0.02 mg/kg.

Treatment:

Drug: Cisatracurium