Effects of Clopidogrel and Clarithromycin on the Oral Disposition of Sibutramine in Healthy Subjects (sibu)

Inje University

Status and phase: Completed; Phase 1

Conditions: Healthy

Treatments: Drug: sibutramine-Clarithromycin; Drug: Sibutramine-clopidogrel

Study type: Interventional

Funder types: Other

Identifiers

NCT01421706

08-073

Details and patient eligibility

About

Effects of clopidogrel and clarithromycin on the oral disposition of sibutramine in healthy subjects

Full description

1. Plasma concentrations of sibutramine and its two active metabolites after single oral dose of sibutramine were determined in Korean healthy male subjects with different CYP2B6 genotypes (CYP2B6*1/*1, *1/*6 and *6/*6), either alone or after four-day pretreatment with clopidogrel or clarithromycin.

Enrollment: 20 patients

Sex: Male

Ages: 19 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• must be healthy volunteer

Exclusion criteria

• must not be under 18 years old

Trial design

20 participants in 2 patient groups

sibutramine-clopidogrel

Active Comparator group

Description:

sibutramine-clopidogrel

Treatment:

Drug: Sibutramine-clopidogrel

sibutramine-clarithromycin

Active Comparator group

Description:

sibutramine-clarithromycin

Treatment:

Drug: sibutramine-Clarithromycin