Effects of Cocoa Flavanols on Human Cognitive Function
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About
To determine the acute and chronic effects of cocoa derived flavonoids on cognitive function in healthy older adults.
Full description
This is a randomised controlled double blind cross over study investigating the acute effects of high flavanol (495mg) compared to low flavanol (23mg)cocoa drink on cognitive function in a healthy older adult population (n=60). The primary outcome measure of this study is to determine the effects of the flavanol intervention on cognitive measures of executive function and attention and the secondary measures of blood pressure and to determine whether any observed effects are paralleled by plasma flavanol levels.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Aged 62 - 75 years
- A signed consent form
Exclusion criteria
- Blood pressure > 160/90 mmHg
- Haemoglobin (anaemia marker) < 125 g/l
- Gamma GT (liver enzymes) > 80 IU/l
- Had suffered a myocardial infarction or stroke in the previous 12 months
- Suffers from any gastrointestinal/stomach disorder
- Suffers from any blood-clotting disorder
- On medication for hypertension
- Suffers from any metabolic disorders (e.g. diabetes or any other endocrine or liver diseases)
- Depression or major mental illness
- Any dietary restrictions or on a weight reducing diet
- Drinking more than 21 units per week
- On any medication affecting blood clotting
- Smoking
- Vegans
Trial design
Primary purpose
Allocation
Interventional model
Masking
63 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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