Effects of Coffee on Hepatic Steatosis Induced by a High Fructose Diet (COLIBRI)

University of Lausanne (UNIL)

Status: Completed

Conditions: Hepatic Steatosis

Treatments: Dietary Supplement: Partially torrefied, caffeinated coffee; Dietary Supplement: High fructose diet; no coffee; Dietary Supplement: fully torrefied, caffeine-free coffee; Dietary Supplement: partially torrefied, caffeine-free coffee; Dietary Supplement: Ctl

Study type: Interventional

Funder types: Other

Identifiers

NCT00827450

COLIBRI

Details and patient eligibility

About

This study will assess

• whether coffee consumption protects against fructose-induced hepatic steatosis in healthy humans
• whether the protective effect of coffee is dependent on it's antioxidant composition

Full description

Epidemiological studies suggest that coffee consumption improves glucose homeostasis in insulin resistant subjects. An increase in intrahepatic lipids (hepatic steatosis) is highly prevalent in patients with the metabolic syndrome and may be used as a marker of altered hepatic lipid metabolism. Such an increased hepatic lipids content can be experimentally produced in healthy humans by a 6-day high fructose diet.

The purpose of this study is to evaluate whether coffee prevents hepatic lipid deposition in healthy male subjects fed a fructose-rich hypercaloric diet. Both caffeine and antioxidants (yet unspecified) may be involved.. To sort out the role of caffeine and antioxidants, we will test 3 different soluble coffee, ie fully torrefied decaffeinated coffee , partially torrefied decaffeinated coffee, and partially torrefied caffeinated coffee.

Enrollment: 13 patients

Sex: Male

Ages: 18 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• BMI between 19 and 15 kg/m2
• less than 30 min physical activity /day
• habitual coffee consumption less than three cupy /day
• consumption of caffeine-containing sodas less than 2 servings/day
• non-smoker

Exclusion criteria

• consumption of alcohol more than 40g/day
• presence of metallic foreign bodies
• history of eye surgery
• family history of diabetes mellitus
• history of food intolerance
• vegetarians

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Quadruple Blind

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13 participants in 5 patient groups, including a placebo group

Ctl

Placebo Comparator group

Description:

control isocaloric diet; no coffee

Treatment:

Dietary Supplement: Ctl

HF

Placebo Comparator group

Description:

Hypercaloric. high fructose diet; no coffee

Treatment:

Dietary Supplement: High fructose diet; no coffee

C1

Experimental group

Description:

Hypercaloric, high fructose diet; caffeine-free, torrefied coffee

Treatment:

Dietary Supplement: fully torrefied, caffeine-free coffee

C2

Experimental group

Description:

Hypercaloric, high fructose diet; caffeine-free, partially torrefied coffee

Treatment:

Dietary Supplement: partially torrefied, caffeine-free coffee

C3

Experimental group

Description:

Hypercaloric, high fructose diet; caffeinated, partially torrefied coffee

Treatment:

Dietary Supplement: Partially torrefied, caffeinated coffee