Effects of Colloid and Crystalloid on the Microcirculatory Alterations During Off-pump Coronary Artery Bypass Surgery

Seoul National University

Status: Completed

Conditions: Cardiac Surgery

Treatments: Drug: plasmalyte solution; Drug: Hextend

Study type: Interventional

Funder types: Other

Identifiers

NCT01713166

YSJeon_crystalloid vs colloid

Details and patient eligibility

About

The purpose of this study is to compare the effects of crystalloid and colloid, which are used for pump priming solution, on the microcirculatory alterations during cardiac surgery.

Enrollment: 120 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Off-pump Coronary Artery Bypass Surgery

Exclusion criteria

• Infection
• Postoperative use of steroid
• Liver cirrhosis, Child-Pugh C
• Renal disease on hemodialysis
• Patients who cannot receive vascular occlusion test (severe peripheral vascular disease, arteriovenous fistula, burn)
• EF < 40% on the preoperative echocardiography
• Preoperative use of vasopressors or inotropic agents

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 2 patient groups

Plasmalyte solution

Active Comparator group

Description:

Plasmalyte solution infusion to meet the fluid requirements.

Treatment:

Drug: plasmalyte solution

Hextend

Experimental group

Description:

6% Hetastarch administeration instead of crystalloids until the total amount given reached 20 ml/kg, which is the maximally allowed daily dose. Afterward, plasmalyte solution infusion to meet the fluid requirements.

Treatment:

Drug: Hextend