Effects of Combined Physical-cognitive Training on Cognitive Function in MCI

Chiang Mai University

Status: Completed

Conditions: Mild Cognitive Impairment

Treatments: Other: Combined physical-cognitive training; Other: Cognitive training; Other: Physical training

Study type: Interventional

Funder types: Other

Identifiers

NCT03805620

AMS-CMU

Details and patient eligibility

About

The present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral BDNF level and mitochondrial function of individuals with MCI. It is hypothesized that: 1) the combined physical-cognitive training program will be superior to the physical and cognitive training program alone; and 2) the degree of cognitive improvement will be positively correlated with the improvement of plasma BDNF and mitochondrial function.

Full description

Recent research suggests that the benefits of combined physical-cognitive training may be greater than either physical or cognitive training alone. Nevertheless, this synergistic effect has been demonstrated mainly in cognitively intact older adults. Studies examining the effects of combined physical-cognitive training in older adults with MCI are scarce and show mixed results. Moreover, few studies have determined the effects of the combined training on peripheral brain-derived neurotrophic factor (BDNF) and mitochondrial function. Thus, the present study aims to investigate the effects of combined physical-cognitive training on cognitive function as well as peripheral BDNF level and mitochondrial function of individuals with MCI. The present study will provide insight into the interplay among the training program, peripheral BDNF concentration, mitochondrial function, and cognitive function. Importantly, the findings will have clinical implication regarding the training program that is feasible and effective in improving cognitive function of older adults with MCI which ultimately will have great impact on public health as this population is at high risk of progression to AD.

Enrollment: 128 patients

Sex: All

Ages: 60 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• meet criteria for mNCD (mild neurocognitive disorders), previously known as MCI, based on the recent DSM-V (Diagnostic Statistical Manual-V) criteria
• comprehend instructions and willing to participate
• able to comply with the study schedule and procedures
• not taking any medications for their cognition and not planning to start medications during the study trial

Exclusion criteria

• presence of medical conditions that would be unsafe to exercise
• diagnosed with other neurological conditions (e.g. Parkinson's disease, Stroke, Multiple Sclerosis, AD) that affect cognition and mobility
• presence of depressive symptoms
• presence of acute or/and chronic disease that could not be controlled (e.g. Arthritis, Asthma, Hypertension, Diabetes mellitus, Coronary artery disease)
• exercise regularly (at least 30 min/day, 3 days/week)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Single Blind

---

128 participants in 4 patient groups

Phys Group

Active Comparator group

Description:

physical training group

Treatment:

Other: Physical training

Cog Group

Active Comparator group

Description:

cognitive training group

Treatment:

Other: Cognitive training

Phys-Cog Group

Experimental group

Description:

combined physical-cognitive training group

Treatment:

Other: Combined physical-cognitive training

Con Group

No Intervention group

Description:

educational control group