Effects of Combined Sevoflurane and Nitrous Oxide Inhalation - 14

The University of Chicago

Status: Completed

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: 0.2% sevoflurane; Drug: 0.4% Sevoflurane; Drug: 30% Nitrous oxide; Other: Placebo

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000262

NIDA-08391-14

R01DA008391 (U.S. NIH Grant/Contract)

R01-08391-14

Details and patient eligibility

About

The purpose of this study is to determine the effects of combined sevoflurane and nitrous oxide inhalation on mood, psychomotor performance, and the pain response in humans.

Enrollment: 20 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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20 participants in 3 patient groups, including a placebo group

Placebo +/- 30% Nitrous oxide

Placebo Comparator group

Treatment:

Other: Placebo

Drug: 30% Nitrous oxide

Sevoflurane 0.2% +/- 30% Nitrous oxide

Active Comparator group

Treatment:

Drug: 0.2% sevoflurane

Drug: 30% Nitrous oxide

Sevoflurane 0.4% +/- 30% Nitrous oxide

Active Comparator group

Treatment:

Drug: 0.4% Sevoflurane

Drug: 30% Nitrous oxide