Effects of Consuming Artificial Sweeteners and Sugar on Cerebral and Physiological Responses (SUGART)

University of Lausanne (UNIL)

Status: Completed

Conditions: Normal Subjects

Treatments: Other: ingestion of a test meal with water; Other: ingestion of a test meal with sweetener

Study type: Interventional

Funder types: Other

Identifiers

NCT02853773

353/15

Details and patient eligibility

About

This study aims at investigating the acute influence of artificially sweetened beverages consumption (as compared with sugar-sweetened beverages and water consumption) on brain responses to the viewing of food images, on physiological responses (gut-derived hormones and lipid metabolites) and on the food intake behavior.

Full description

This study is made on a randomized controlled crossover design including three conditions (water, sugar, artificial sweeteners). Measurements will be performed in fasting and fed conditions. The test-meal will comprise either an artificially or sugar-sweetened beverage or water (control). The spatio-temporal brain dynamics to the viewing of food pictures will be assessed by means of electroencephalography (EEG) recordings and electrical neuroimaging analyses. Venous blood and urine will be collected. Blood pressure, cardiac frequency and bio-impedance measurements will be performed. Food intake behavior will be assessed by means of questionnaires and a free-choice buffet. Each tested condition (water, sugar, artificial sweeteners) will be preceded by a run-in period during which the participants' diet will be controlled (2-day isoenergetic diet).

Enrollment: 18 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Caucasian
• Right-handed
• Weak to normal physical activity (< 3hours per week)
• Normal-weight (19<BMI<25 kg/m2)
• Regular consumption of sugar-sweetened beverages (>33cl per week)

Exclusion criteria

• Consumption of artificially sweetened beverages exceeding 33cl per week
• Diabetes
• Cardiovascular, kidney, hepatic and/or psychological disorders
• Blood pressure at rest > 140/90mmHg
• Body weight < 50kg
• Hemoglobin < 13.5g/dl
• Ferritin < 50microg/l
• Drug consumption
• Alcohol consumption (>10g/day)
• Smoking
• Any particular diet (e.g. vegetarianism), food allergy and/or intolerance
• Body weight gain or loss of >3kg during the last 3 months

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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18 participants in 3 patient groups

Artificial sweetener

Experimental group

Description:

Effects of co-ingestion of artificially sweetened beverage on the response to a test meal

Treatment:

Other: ingestion of a test meal with sweetener

Other: ingestion of a test meal with sweetener

Sugar

Active Comparator group

Description:

Effects of co-ingestion of sugar-sweetened beverage on the response to a test meal

Treatment:

Other: ingestion of a test meal with sweetener

Other: ingestion of a test meal with sweetener

Water

Active Comparator group

Description:

Effects of co-ingestion of water on the response to a test meal

Treatment:

Other: ingestion of a test meal with water