Effects of Consuming Sugar-Sweetened Beverages With Meals for 10 Weeks (IPOP)

University of California (UC) Davis

Status

Completed

Conditions

Insulin Resistance

Dyslipidemia

Metabolic Syndrome

Treatments

Other: Fructose

Other: Glucose

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT01165853

R01HL075675 (U.S. NIH Grant/Contract)

200412368

Details and patient eligibility

About

The purpose of this study is compare the effects of consuming glucose- and fructose-sweetened beverages on appetite, body weight, body fat, and the amount of energy the body burns as well as effects on blood pressure, hormones, blood triglycerides and cholesterol, and the body's sensitivity to the insulin.

Full description

The study is designed as a prospective, blinded diet intervention study during which the participants consume either fructose- or glucose-sweetened beverages (25% of energy) with meals. Experimental procedures, including 24-hour serial blood sampling, 26-h stable isotoped infusions, post-heparin blood collection, gluteal biopsies, metabolic rate monitoring, computed tomography scans of the abdomen, and Oral Glucose Tolerance and Disposal Tests, are performed during baseline and at the end of a 10-week intervention period at the UC Davis School of Medicine/Sacramento Veterans Affairs Medical Center Clinical Research Center (CCRC). During the 2-week inpatient baseline period, subjects are served energy balanced diets containing 15% of energy as protein, 30% as fat, and 55% as complex carbohydrate. Following the baseline period, the subjects reside at home for 8 weeks and consume their usual ad libitum diet along with 25% of energy requirements as fructose- or glucose-sweetened beverages. Subjects then return to the CCRC for the 2-week inpatient intervention period at the end of the study and are served energy-balanced diets containing 15% of energy as protein, 30% as fat, 30% as complex carbohydrate and 25% of energy as fructose- or glucose-sweetened beverage.

Enrollment

32 patients

Sex

All

Ages

40 to 72 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Self-report of stable body weight
Women were post-menopausal based on a self-report of no menstruation for at least one year

Exclusion criteria

evidence of diabetes
renal or hepatic disease
fasting serum TG concentrations >400 mg/dl
hypertension (>140/90 mg Hg)
surgery for weight loss
individuals who smoked
reported exercise of more than 3.5 hours/week at a level more vigorous than walking
having used thyroid, lipid-lowering, glucose-lowering, anti-hypertensive, anti-depressant, or weight loss medications
habitual ingestion of more than one sugar-sweetened beverage/day or more than two alcoholic beverages/day