Protective Effect of CoQ10 Against Negative Inflammatory Response and Organ Dysfunction in Cardiovascular Surgery (PANDA V)

Nanjing Medical University

Status: Enrolling

Conditions: Cardiovascular Disease

Treatments: Dietary Supplement: Standard Medical Therapy; Drug: Coenzyme Q10

Study type: Interventional

Funder types: Other

Identifiers

NCT04444349

PANDA V

Details and patient eligibility

About

Cardiovascular diseases are the leading causes of death and prescription drug use. Research on certain dietary supplements looks promising as a way to help reduce risk factors. Previous studies showed that CoQ10 levels were decreased in cardiovascular patients and worsening of mitochondrial dysfunction was observed. The overall objective of this study is to determine if supplementing with CoQ10 can reduce inflammatory risk factors in adults with cardiac surgery, independent of other dietary or physical activity changes.

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult men and women
• Who receive cardiovascular surgery
• Agree to participate in the surgery and sign the informed consent form

Exclusion criteria

• Pregnant or planning on getting pregnant during the study
• Contain a minimum of 2 traits of metabolic syndrome
• Refused to participate in the surgery and refused informed consent

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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500 participants in 2 patient groups

Coenzyme Q10 group

Experimental group

Description:

Participants in the experimental group will be given 10mg of Coenzyme Q10 each time (3 times a day).

Treatment:

Drug: Coenzyme Q10

Control

Sham Comparator group

Description:

patients only receive standard medical therapy.

Treatment:

Dietary Supplement: Standard Medical Therapy