Effects of Core Stabilization Exercises in Children with Acute Lymphoblastic Leukemia

Karamanoğlu Mehmetbey University

Status: Enrolling

Conditions: Acute Lymphoblastic Leukemia

Treatments: Other: Conventional exercises; Other: Core stabilization exercises in addition to conventional exercises

Study type: Interventional

Funder types: Other

Identifiers

NCT06794762

2024/023-12

Details and patient eligibility

About

The goal of this clinical trial is to investigate the effects of core stabilization exercises applied in addition to the conventional exercise program on physical function, functional muscle strength, functional exercise capacity, postural control and fatigue in children with acute lymphoblastic leukemia receiving maintenance treatment.

Participants will be divided into two groups; the first group will be given a conventional exercise program, while the second group will be given core stabilization exercises in addition to the conventional exercise program.

Full description

Acute Lymphoblastic Leukemia (ALL) is a malignancy resulting from the abnormal proliferation of lymphoid cells that can invade the bone marrow, blood, and extramedullary regions, and it is the most common malignancy in childhood. Specific chemotherapy-related problems are frequently observed in children with ALL. These include a reduction in cardiopulmonary fitness, balance, posture, proximal muscle strength, and flexibility, as well as postural control issues and functional mobility impairments, in addition to fatigue.

The aim of this study is to investigate the effects of core stabilization exercises, applied in addition to a conventional exercise program, on physical function, functional muscle strength, functional exercise capacity, postural control, and fatigue in children with Acute Lymphoblastic Leukemia undergoing maintenance therapy.

Participants will be divided into two groups: the first group will follow a conventional exercise program, while the second group will receive core stabilization exercises in addition to the conventional program. All participants will be randomly assigned to the groups using the software available at http://www.randomizer.org. The exercise sessions will be conducted three times a week for a total of 8 weeks, with 24 sessions in total. Demographic information will be recorded for participants who agree to take part in the study and meet the inclusion criteria. The scales and tests designed to assess the participants' physical function, functional muscle strength, functional exercise capacity, postural control, and fatigue will be administered both before and after the study.

Enrollment: 34 estimated patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children aged 7-18
• Diagnosed with ALL
• In the maintenance phase of chemotherapy
• Children without acute thrombosis, active ischemia, hemodynamic instability
• Children without uncontrolled pain
• Children who can follow verbal instructions.

Exclusion criteria

• Children who have received or are receiving cranial radiotherapy
• Children with any cardiovascular disease, acute or chronic respiratory disease
• Children with acute or chronic bone, joint, muscle problems
• Children diagnosed with neuromotor deficits or genetic disorders
• Children with vision problems other than refractive errors

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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34 participants in 2 patient groups

Control group

Experimental group

Description:

Exercises will be applied to the participants participating in the study 3 days a week, 8 weeks, and 24 sessions in total.

Treatment:

Other: Conventional exercises

Intervention group

Experimental group

Description:

Exercises will be applied to the individuals participating in the study 3 days a week, 8 weeks, and 24 sessions in total. Exercises will be applied after the conventional therapy sessions.

Treatment:

Other: Core stabilization exercises in addition to conventional exercises