Effects of Creatine and Glucoseamine/ Chondritin Sulfate Co-Supplementation in Addition to Exercise and Physical Therapy in Patients With Knee Osteoarthritis

F

Foundation University Islamabad

Status

Unknown

Conditions

Knee Osteoarthritis

Treatments

Dietary Supplement: Creatine Supplementation
Device: Electrotherapy + Heating
Dietary Supplement: Glucoseamine/ Chondritin Sulfate Supplementation
Procedure: Joint Mobilization
Other: Home Exercise Plan
Other: Lower Extremity Resistance Exercise Training

Study type

Interventional

Funder types

Other

Identifiers

NCT04423432
FUI/CTR/2020/4

Details and patient eligibility

About

Osteoarthritis is the 11th highest contributor to disability world wide. In terms of conservative management of patients with knee osteoarthritis, Resistance exercise has been shown to be an effective intervention for reducing pain and cartilage degeneration and improving muscle strength, joint biomechanics and physical functioning. But, research shows that co supplementation can further augment the effects of resistance exercise. However, it is imperative to point out that the existing evidence is majorly focused on the individual effects of resistance exercise training and non-pharmacological supplementation, and is still deficient in the effects of co-supplementation in addition to resistance exercise training in patients with knee osteoarthritis.

Enrollment

36 estimated patients

Sex

All

Ages

40 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age 40-70 years
  • Knee OA with history not less than three months.
  • Radiological evidences of grade III or less on Kellgren classification.
  • Knee pain on VNRS no more than 8/10

Exclusion criteria

  • Neuromuscular conditions that may lead to fatigue such as multiple Sclerosis
  • Signs of serious pathology (e.g., malignancy, inflammatory disorder, infection).
  • History of trauma or fractures in lower extremity.
  • Signs of lumbar radiculopathy or myelopathy.
  • History of knee surgery or replacement.
  • Patients on intra-articular steroid therapy within two months before the commencement of the study.
  • Impaired skin sensation.
  • Impaired renal function

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

36 participants in 3 patient groups

Control
Active Comparator group
Treatment:
Other: Lower Extremity Resistance Exercise Training
Other: Home Exercise Plan
Procedure: Joint Mobilization
Device: Electrotherapy + Heating
Creatine Supplementation
Experimental group
Treatment:
Other: Lower Extremity Resistance Exercise Training
Other: Home Exercise Plan
Procedure: Joint Mobilization
Dietary Supplement: Creatine Supplementation
Device: Electrotherapy + Heating
Glucoseamine/ Chondritin Sulfate Supplementation
Experimental group
Treatment:
Other: Lower Extremity Resistance Exercise Training
Other: Home Exercise Plan
Procedure: Joint Mobilization
Dietary Supplement: Glucoseamine/ Chondritin Sulfate Supplementation
Device: Electrotherapy + Heating

Trial contacts and locations

1

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Central trial contact

Muhammad Osama, PhD*

Data sourced from clinicaltrials.gov

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