Effects of Creatine Supplementation in Addition to Resistance Exercise Training in Patients With Knee Osteoarthritis

Foundation University Islamabad

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Other: Lower Extremity Resistance Exercise Training; Procedure: Joint Mobilization; Dietary Supplement: Creatine Supplementation; Device: Electrotherapy + Heating; Other: Home Exercise Plan

Study type: Interventional

Funder types: Other

Identifiers

NCT04423887

FUI/CTR/2020/5

Details and patient eligibility

About

Despite the past decade being dedicated to bone and joint disease, the incidence and prevalence rates of osteoarthritis continues to rise, and till date not curative treatment has been identified for the management of knee osteoarthritis. In terms of conservative management of knee osteoarthritis, pharmacological management has been the mainstay of treatment, however is associated with numerous adverse effects with prolonged use, and it is important to look into the non-pharmacological alternates for the management of knee osteoarthritis. Research has shown resistance exercise training to be the most effective non-pharmacological treatment option for the management of knee osteoarthritis, and the purpose of the current study is to determine if the addition of a non-pharmacological dietry supplement like creatine can amplify the beneficial effects of resistance exercise training in patients with knee osteoarthritis.

Enrollment: 24 patients

Sex: All

Ages: 40 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 40-70 years
• Knee OA with history not less than three months.
• Radiological evidences of grade III or less on Kellgren classification.
• Knee pain on VNRS no more than 8/10

Exclusion criteria

• Neuromuscular conditions that may lead to fatigue such as multiple Sclerosis
• Signs of serious pathology (e.g., malignancy, inflammatory disorder, infection).
• History of trauma or fractures in lower extremity.
• Signs of lumbar radiculopathy or myelopathy.
• History of knee surgery or replacement.
• Patients on intra-articular steroid therapy within two months before the commencement of the study.
• Impaired skin sensation.
• Impaired renal function

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups

Control

Active Comparator group

Treatment:

Device: Electrotherapy + Heating

Other: Home Exercise Plan

Procedure: Joint Mobilization

Other: Lower Extremity Resistance Exercise Training

Creatine Supplementation

Experimental group

Treatment:

Dietary Supplement: Creatine Supplementation

Device: Electrotherapy + Heating

Other: Home Exercise Plan

Procedure: Joint Mobilization

Other: Lower Extremity Resistance Exercise Training