Effects of Crossover Point Exercise on Vascular Function of Women in Different Menopausal Years

B

Beijing Sport University

Status

Enrolling

Conditions

Vascular Health

Treatments

Other: COP exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT06201312
EOCPEOVFOWIDMY

Details and patient eligibility

About

Recruit postmenopausal women and randomly assign them to one of four groups: Early Postmenopausal Exercise Group (EE), Late Postmenopausal Exercise Group (LE), Early Postmenopausal Control Group (EC), and Late Postmenopausal Control Group (LC). All participates will undergo a graded exercise test to determine their maximum oxygen uptake, and vascular function response will be measured immediately after the exercise test. The COP exercise intensity for postmenopausal women will be obtained through the exercise test, and subjects in the EE and LE groups will undergo exercise training at this intensity for a period of three months. Tests and analyses of relevant indicators will be conducted on subjects in all four groups before and after the intervention. The exercise load experiments will be performed on a cycle ergometer.

Enrollment

120 estimated patients

Sex

Female

Ages

45 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Postmenopausal women without cardiovascular disease

Exclusion criteria

  • Women with undetermined menopause
  • BMI <18.5 kg/m2 or BMI >28 kg/m2
  • fasting plasma triglyceride levels ≥500 mgdl
  • diabetes mellitus or fasting glucose >140 mgd
  • blood creatinine >2.0 mgdl
  • uncontrolled hypertension (systolic blood pressure >160 mmHg and/or diastolic blood pressure >110 mmHg)
  • untreated thyroid disease
  • life-threatening illness with a prognosis of <5 years;
  • history of deep vein thrombosis,
  • pulmonary embolism, or breast cancer;
  • currently receiving estrogen therapy.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

120 participants in 4 patient groups

Early Postmenopausal Exercise Group (EE)
Experimental group
Treatment:
Other: COP exercise
Late Postmenopausal Exercise Group (LE)
Experimental group
Treatment:
Other: COP exercise
Early Postmenopausal Control Group (EC)
No Intervention group
Late Postmenopausal Control Group (LC)
No Intervention group

Trial contacts and locations

1

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Central trial contact

Peizhen Zhang

Data sourced from clinicaltrials.gov

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