Effects of Daily Supplementation of 5-HTP on Body Composition

Nova Southeastern University (NSU)

Status: Completed

Conditions: Body Composition

Treatments: Other: Placebo; Dietary Supplement: 5-HTP

Study type: Interventional

Funder types: Other

Identifiers

NCT05216406

102

Details and patient eligibility

About

The purpose of this investigation was to compare supplementation with 5-HTP to placebo on indices of body composition. A randomized trial compared a sample of 48 resistance-trained individuals taking either 100 mg of 5-hydroxytryptophan supplementation or a placebo.

The investigators tested anthropometric measurements using a multi-frequency bioelectrical impedance device (InBody® 270). The primary outcome (i.e., changes in anthropometric measurements) was assessed at the first visit (pre-test-) and post-test (8 weeks). Secondary outcomes include resting heart rate, blood pressure, and dietary intake.

Enrollment: 65 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy or free of disease
• Minimum of 1 year of regular physical activity. Regular physical activity is defined by a minimum of 150 minutes of aerobic activity or performing muscle-strengthening exercises at least 2 days a week.

Exclusion criteria

• Physically inactive
• Regularly used sleep aids of any kind
• Currently taking selective serotonin reuptake inhibitors (SSRIs) and/or 5-HTP containing supplements.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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65 participants in 2 patient groups, including a placebo group

5-HTP

Experimental group

Description:

The dietary supplement (100 mg of 5-hydroxytryptophan; CLEANMOOD™) was provided by NURA™ (Irvine, California USA). Subjects were instructed to consume one capsule daily at their convenience for 8 weeks.

Treatment:

Dietary Supplement: 5-HTP

Control

Placebo Comparator group

Description:

The placebo consisted of maltodextrin. Subjects were instructed to consume one capsule daily at their convenience for 8 weeks.

Treatment:

Other: Placebo