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Effects of Daily Taurine Intake for 6 Months on Biological Age and Body Metabolism Indicators As Well As Physical Fitness in 55-75-year-old Women and Men (TauAge)

T

Technical University of Munich

Status

Enrolling

Conditions

DNA Methylation
Taurine
Anti-Aging
Physical Activity
Sport
Aging, Biological
Longevity
Metabolic Health
Dietary Supplement

Treatments

Dietary Supplement: Placebo
Dietary Supplement: 4g of taurine daily

Study type

Interventional

Funder types

Other

Identifiers

NCT06613542
2024-253-S-CB

Details and patient eligibility

About

The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months. It will also check for effects of taurine on participant's physical fitness, metabolic and cognitive functions. The main question it aims to answer is:

• Does a supplementation with 4 g of taurine daily over a period of 6 months slow down biological aging in humans? Researchers will compare supplementation with taurine to a placebo (a look-alike substance that contains no drug) to reliably determine whether taurine has an effect.

Participants will:

  • Take 4g of taurine or a placebo every day for 6 months
  • Visit the study site 4 times for checkups and tests: for a screening visit, at the beginning of the intervention, after 8 and 24 weeks

Full description

Measurements performed during study visits:

  • Biological age estimate via proteome analysis
  • Organ age estimates (proteomics)
  • DNA methylation
  • Inflammatory biomarkers (CRP, cytokines)
  • Metabolic variables: fasting blood glucose, insulin, HOMA-IR, HbA1c, lipids, BMI
  • Physical fitness (hand grip strength, leg extensor strength, PWC130)
  • Resting energy expenditure
  • Cognitive function via questionnaire
  • Quality of life
  • Heart rate variability
  • Physical activity, nutrition

Enrollment

80 estimated patients

Sex

All

Ages

55 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • women or men
  • Age 55 - 75
  • BMI 22 - 30 kg/m²
  • written consent

Exclusion criteria

  • Acute or chronic inflammation (e.g. flu infection)
  • Severe chronic illness (e.g., Type 1 or Type 2 diabetes mellitus, COPD, renal insufficiency)
  • Myocardial infarction or stroke in the previous 6 months
  • Psychiatric disorder, including depression or dementia
  • Weight change of ≥ 5 kg in the last 6 months

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

80 participants in 2 patient groups, including a placebo group

4g of taurine daily
Active Comparator group
Description:
Intervention group (4g of taurine/day): 2g of taurine (4 capsules, 500mg each) in the morning and 2g of taurine (4 capsules, 500mg each) in the evening for 6 months
Treatment:
Dietary Supplement: 4g of taurine daily
Placebo
Placebo Comparator group
Treatment:
Dietary Supplement: Placebo

Trial contacts and locations

1

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Central trial contact

Hans Hauner, Prof. Dr. med.; Henning Wackerhage, Prof. Dr.

Data sourced from clinicaltrials.gov

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