Effects of Daily Taurine Intake for 6 Months on Biological Age and Body Metabolism Indicators As Well As Physical Fitness in 55-75-year-old Women and Men (TauAge)

Technical University of Munich

Status: Enrolling

Conditions: DNA Methylation; Taurine; Anti-Aging; Physical Activity; Sport; Aging, Biological; Longevity; Metabolic Health; Dietary Supplement

Treatments: Dietary Supplement: Placebo; Dietary Supplement: 4g of taurine daily

Study type: Interventional

Funder types: Other

Identifiers

NCT06613542

2024-253-S-CB

Details and patient eligibility

About

The goal of this clinical trial is to investigate the effect of taking 4 grams of taurine by older adults on aging processes over a period of 6 months. It will also check for effects of taurine on participant's physical fitness, metabolic and cognitive functions. The main question it aims to answer is:

• Does a supplementation with 4 g of taurine daily over a period of 6 months slow down biological aging in humans? Researchers will compare supplementation with taurine to a placebo (a look-alike substance that contains no drug) to reliably determine whether taurine has an effect.

Participants will:

• Take 4g of taurine or a placebo every day for 6 months
• Visit the study site 4 times for checkups and tests: for a screening visit, at the beginning of the intervention, after 8 and 24 weeks

Full description

Measurements performed during study visits:

• Biological age estimate via proteome analysis
• Organ age estimates (proteomics)
• DNA methylation
• Inflammatory biomarkers (CRP, cytokines)
• Metabolic variables: fasting blood glucose, insulin, HOMA-IR, HbA1c, lipids, BMI
• Physical fitness (hand grip strength, leg extensor strength, PWC130)
• Resting energy expenditure
• Cognitive function via questionnaire
• Quality of life
• Heart rate variability
• Physical activity, nutrition

Enrollment: 80 estimated patients

Sex: All

Ages: 55 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women or men
• Age 55 - 75
• BMI 22 - 30 kg/m²
• written consent

Exclusion criteria

• Acute or chronic inflammation (e.g. flu infection)
• Severe chronic illness (e.g., Type 1 or Type 2 diabetes mellitus, COPD, renal insufficiency)
• Myocardial infarction or stroke in the previous 6 months
• Psychiatric disorder, including depression or dementia
• Weight change of ≥ 5 kg in the last 6 months

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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80 participants in 2 patient groups, including a placebo group

4g of taurine daily

Active Comparator group

Description:

Intervention group (4g of taurine/day): 2g of taurine (4 capsules, 500mg each) in the morning and 2g of taurine (4 capsules, 500mg each) in the evening for 6 months

Treatment:

Dietary Supplement: 4g of taurine daily

Placebo

Placebo Comparator group

Treatment:

Dietary Supplement: Placebo