Effects of Daily Walnut Intake Among the Subjects With Metabolic Syndrome

ICAN Nutrition Education and Research

Status

Completed

Conditions

Metabolic Syndrome

Treatments

Other: food

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT03267901

CWC-2016-MetS

Details and patient eligibility

About

Investigators planed to conduct a randomized, controlled, crossover trial to examine the effects of daily walnuts intake among Korean subjects with metabolic syndrome. Primary objective of this study was to investigate the effects of daily walnut intake on changes of metabolic syndrome indices in Koreans with metabolic syndrome age over 30 years old. This study was consisted of four periods: run-in, first intervention, wash-out, and second intervention phases. As 16 weeks of first intervention period began after the run-in phase, the subjects were randomly assigned into one of two groups: walnut group and control group. Participants in walnut group consumed 45 grams of walnuts on a daily basis and participants in control group were provided iso-caloric white bread for first 16 weeks. After the first intervention and wash-out period (6 weeks), second intervention which is crossover of first intervention was started during the next 16 weeks. Anthropometric measurements and biochemical analyses were done at the beginning and the end of each intervention (0, 16, 22, and 38 weeks of trial). Habitual diet was randomly observed using 3-day diet record once during each phase.

Investigators expected to evaluate 1)effects of walnut ingestion on reverting metabolic syndrome to normal status especially by reducing waist circumference and improving serum levels of triglyceride and high-density lipoprotein, 2)beneficial effects of daily walnut consumption on changes of body composition in the subjects with metabolic syndrome, and 3)regulatory effects of daily walnut intake on inflammatory markers and diabetic markers.

Enrollment

119 patients

Sex

All

Ages

30 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: at least three out of five metabolic syndrome components

waist circumference (WC) >90 cm for men and >80 cm for women
hypertension (DBP ≥85 and <110 mm Hg)
hyperglycemia (≥100 mg/dL)
elevated plasma TG concentrations (≥150 mg/dL)
decreased plasma HDL-C concentrations (<40 mg/dL for men and <50 mg/dL for women)

Exclusion Criteria:

the presence of morbid obesity (BMI ≥40)
the use of any medication for the control of blood pressure, glucose, or lipid metabolism
a medical history of hypocaloric diet consumption within the past year
gastrointestinal tract disorders
post-menopausal women
smokers