Effects of Denture-Related Stomatitis on Blood Pressure in Denture Wearers

Jagiellonian University

Status: Unknown

Conditions: Denture Stomatitis

Treatments: Drug: Nystatin

Study type: Observational

Funder types: Other

Identifiers

NCT02166450

DRS-001

Details and patient eligibility

About

The aim of this study is to evaluate the influence of presence of oral fungal infection, which leads to denture-related stomatitis, on blood pressure, endothelial function and immune cell phenotype in patients wearing dentures.

Enrollment: 80 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with dental prostheses used for at least 6 months,
• Substantial portion of the oral mucosa covered by dental prosthesis.

Exclusion criteria

• acute inflammatory disorders other than denture-related stomatitis, neoplastic disease relapses or chemotherapy courses less than 5 years before the enrolment,
• antibiotics in less than 4 weeks before the enrolment,
• anti-inflammatory drugs (steroids and non-steroidal, excluding aspirin in doses less than 80 mg) in less than 2 months before the enrolment,
• history of myocardial infarction, acute coronary incident or vascular inflammation in 5 weeks or less before the enrolment,
• chronic haematological disorders and immunodeficiencies less than 5 weeks before the enrolment,
• major medication changes less than 5 weeks before the enrolment or during study.

Trial design

80 participants in 2 patient groups

Control group

Description:

Denture wearers without clinical signs of denture-related stomatitis confirmed with negative Candida swabs.

Denture-related stomatitis group

Description:

Denture wearers with clinical signs of denture-related stomatitis, confirmed with positive Candida swabs. Treated for fungal infection, with nystatin \[100 000 IU every 6 h for 3 weeks, applied on the infected area of the mucous membrane of the palate and cheeks\].

Treatment:

Drug: Nystatin