Effects of Desflurane and Propofol During Lung Volume Reduction Surgery

Columbia University

Status and phase: Completed; Phase 4

Conditions: Lung Volume Reduction Surgery

Treatments: Drug: Propofol; Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT04226625

AAAR3687

9340

Details and patient eligibility

About

Patients presenting for lung volume reduction are very high risk patients and it is important they receive the best anesthetic available. This study aims to answer which is the best anesthetic for managing such cases.

Full description

The anesthetic technique for lung volume reduction surgery consists of a thoracic epidural in combination with a general anesthetic. The thoracic epidural is routine for this operation and allows administration of local anesthetics and painkillers in the epidural space which results in profound pain relief in the area of surgery. The epidural is routinely used for pain control during the surgery and after the surgery when the patient is awake.

The general anesthetic used may be a volatile agent (gas for example Desflurane), which is administered through the anesthesia machine, or an intravenous anesthetic agent, which is administered into a vein through an intravenous line as a continuous infusion (example Propofol). The use of an anesthetic agent and an epidural often causes a decrease in blood pressure which is treated with medication. The investigators are comparing the two anesthetic techniques regarding their effect on blood pressure and the amount of medication needed to treat it.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Scheduled to undergo lung volume reduction surgery (LVRS)

Exclusion criteria

• Does not sign a study consent form

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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18 participants in 2 patient groups

Propofol

Active Comparator group

Description:

Patients will receive Propofol as an intravenous (IV) agent, which is administered into a vein through an IV line as a continuous infusion.

Treatment:

Drug: Propofol

Desflurane

Active Comparator group

Description:

Patients will receive Desflurane as a gas that is administered through an anesthesia machine.

Treatment:

Drug: Desflurane