Effects of Dexamethasone on Common Bile Duct Cannulation Time

Gujranwala medical college District Headquarters Hospital, Gujranwala

Status: Completed

Conditions: Common Bile Duct Stricture; Common Bile Duct Dilatation; Common Bile Duct Diseases; Common Bile Duct Neoplasms; Common Bile Duct Calculi

Treatments: Drug: Dexamethasone 4mg

Study type: Interventional

Funder types: Other

Identifiers

NCT05945797

001

Details and patient eligibility

About

The main aim of this clinical trial is to evaluate the effects of dexamethasone on common bile duct cannulation time during endoscopic retrograde cholangiopancreatography (ERCP) in patients with biliary pathologies. The study will also study the effects of dexamethasone on total procedure time and total fluoroscopy time during ERCP.

Participants will be divided into two groups, treatment group and placebo group. Patients in treatment group will receive dexamethasone and those in placebo group will be given normal saline before undergoing ERCP. The results in both groups will be compared to determine the effects of dexamethasone.

Enrollment: 80 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age: 18 years or above
• Both genders, male and female patients

Exclusion criteria

• Age younger than 18 years or below
• Pregnant females
• Pre existing stent in CBD or pancreatic duct
• Previous history of ERCP
• Patients with billroth II surgery
• Anatomical abnormalities
• Lack of competence in patients
• Roux en Y gastric bypass
• Patients with contra indications for steroids like DM

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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80 participants in 2 patient groups, including a placebo group

Dexa Arm

Experimental group

Description:

Experimental arm patients will be receiving 2 ml (4mg) of dexamenthasone prior to undergoing ERCP.

Treatment:

Drug: Dexamethasone 4mg

NS Arm

Placebo Comparator group

Description:

Placebo arm patients will be receiving 2 ml of normal saline prior to undergoing ERCP.

Treatment:

Drug: Dexamethasone 4mg