Effects of Dexmedetomidine and Propofol on Pulmonary Mechanics

Çukurova University

Status and phase: Completed; Phase 4

Conditions: Abnormal Respiratory Airway Resistance

Treatments: Drug: propofol; Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02330120

intensive care

Details and patient eligibility

About

The aim of this study is to compare the effects of dexmedetomidine and propofol on pulmonary mechanics in intensive care patients.

Full description

The aim of this study is to compare the effects propofol and dexmedetomidine on pulmonary mechanics. Sixty patients mechanically ventilated in intensive care unit are included in this study. Patients are divided into two random groups, Group P (propofol) and Group D (dexmedetomidine). Propofol infusion 0.5-2 mg/kg/h is given to Group P patients and dexmedetomidine infusion 0.2-0.7 mcg/kg/h is given to Group D patients for sedation. Initial blood gas analysis, airway resistance (cmH2O/L/sec), positive end-expiratory pressure (PEEP, cmH20), frequency (breath/min), tidal volume (mL/min), minute volume (mL), peak airway pressure (cmH20), compliance (mL/cmH20), endtidal CO2 (mmHg), SvO2 (%) values are recorded. This parameters are evaluated with Drager Evita 4 ventilator and recorded on 5th,15th,30th,45th ve 60th minutes . Sedation is observed using Riker and Ramsey Sedation-Agitation Scale. Compliance of patients to mechanical ventilation is observed and recorded.

The primary outcome measures are airway resistance and peak airway pressure. Secondary outcome measure is sedation score.

Enrollment: 64 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The patients mechanically ventilated in intensive care unit

Exclusion criteria

• Patients with contraindications for using propofol and dexmedetomidine

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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64 participants in 2 patient groups

propofol

Experimental group

Description:

Propofol infusion 0.5-2 mg/kg/h for sedation in mechanically ventilated patients

Treatment:

Drug: propofol

dexmedetomidine

Active Comparator group

Description:

dexmedetomidine infusion 0.2-0.7 mcg/kg/h for sedation in mechanically ventilated patients

Treatment:

Drug: dexmedetomidine