Effects of Dexmedetomidine on Activity in the Subthalamic Nucleus

University of Wisconsin (UW)

Status and phase: Completed; Phase 4

Conditions: Deep Brain Stimulation Surgery; Parkinson's Disease

Treatments: Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT01721460

2012-0400

Details and patient eligibility

About

The purpose of this research study is to find out whether dexmedetomidine changes brain cell activity in the subthalamic nucleus (STN).

Full description

In order to find whether dexmedetomidine is optimal for sedation during Deep brain stimulation surgery, we will measure the electrical activity in the STN during Deep brain stimulation surgery, and measure how this activity is changed during administration of Dexmedetomidine. We hypothesize that dexmedetomidine does not change the firing rate and pattern in the STN.

Enrollment: 6 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled to undergo bilateral STN electrode implantation surgery with Micro-electrode recording for the treatment of Parkinson's disease.

Exclusion criteria

• Hypersensitivity to dexmedetomidine
• Bradycardia: Sinus rhythm slower than 50 bpm
• Known or suspected obstructive sleep apnea
• Suspected difficult intubation
• Pregnancy
• Under 18 years of age or over 85 years of age
• Cognitive disability impairing understanding the experiment or signing the informed consent form

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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6 participants in 1 patient group

Dexmedetomidine during MER

Experimental group

Description:

The study is performed in patients undergoing DBS electrode implantation to their STN for the treatment of parkinson's disease. Microelectrode recording (MER) is performed as part of STN electrode implantation surgery, to increase the precision of the stimulating electrode placement. The study includes administration of dexmedetomidine while recording electrical activity at a single location to evaluate the effects of this drug on the MER.

Treatment:

Drug: Dexmedetomidine