Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations

Cairo University (CU)

Status and phase: Completed; Phase 4

Conditions: Restrictive Lung Disease

Treatments: Drug: Dexmedetomidine; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02843698

N-12-2016

Details and patient eligibility

About

The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients

Full description

The patients of interest are morbid obese patients scheduled for bariatric surgery. Dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung mechanics (dead space and compliance) as well as oxygenation (PF ratio) will be monitored intraoperatively and postoperatively

Enrollment: 42 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Morbid obese (body mass index > 40) with documented restrictive lung disease scheduled to bariatric operation.

Exclusion criteria

• Heart failure
• ِِِِArrhythmia
• Heart block
• Severe liver or kidney impairment.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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42 participants in 2 patient groups, including a placebo group

Dexmedetomidine group

Experimental group

Description:

Patients will receive either, Dexmedetomidine (Precedex, Hospira, Lake forest, IL, USA) in a dose of (1ug/Kg LBW) bolus followed by 0.5ug/Kg continuous infusion for one hour

Treatment:

Drug: Dexmedetomidine

Control group

Placebo Comparator group

Description:

Patients will receive normal saline

Treatment:

Drug: Normal saline