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Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations

Cairo University (CU) logo

Cairo University (CU)

Status and phase

Completed
Phase 4

Conditions

Restrictive Lung Disease

Treatments

Drug: Dexmedetomidine
Drug: Normal saline

Study type

Interventional

Funder types

Other

Identifiers

NCT02843698
N-12-2016

Details and patient eligibility

About

The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients

Full description

The patients of interest are morbid obese patients scheduled for bariatric surgery. Dexmeditomidine will be infused intraoperatively after induction of anesthesia. lung mechanics (dead space and compliance) as well as oxygenation (PF ratio) will be monitored intraoperatively and postoperatively

Enrollment

42 patients

Sex

All

Ages

18 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Morbid obese (body mass index > 40) with documented restrictive lung disease scheduled to bariatric operation.

Exclusion criteria

  • Heart failure
  • ِِِِArrhythmia
  • Heart block
  • Severe liver or kidney impairment.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

42 participants in 2 patient groups, including a placebo group

Dexmedetomidine group
Experimental group
Description:
Patients will receive either, Dexmedetomidine (Precedex, Hospira, Lake forest, IL, USA) in a dose of (1ug/Kg LBW) bolus followed by 0.5ug/Kg continuous infusion for one hour
Treatment:
Drug: Dexmedetomidine
Control group
Placebo Comparator group
Description:
Patients will receive normal saline
Treatment:
Drug: Normal saline

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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