Effects of Dexmedetomidine on Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery
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About
Dexmedetomidine is a selective α2 adrenergic agonist that can be considered analgesics, anxiolytic,and anti-stress effect . This randomized, double-blind placebo-controlled trial of intraoperative dexmedetomidine for improvement of quality of recovery and analgesia from surgery. Patients scheduled to undergo video-assisted thoracoscopic surgery (VATS) will be enrolled. Patients will be recruited before the date of their surgery and will complete the Quality of Recovery-40 (QoR-40) questionnaire before their surgery and at 24 and 48 hours post op. They will also complete clinically significant pains score and oxygenation from the postanesthetic recovery unit (PACU).
Enrollment
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Inclusion criteria
- The inclusion criteria included patients scheduled video-assisted thoracoscopic surgery for lung cancer
- Adults above 20 years of age and providing informed consent.
- American Society of Anesthesiologists (ASA) Physical class II, & III patients
Exclusion criteria
- severe functional liver or kidney disease
- history of chronic pain requiring opioid treatment
- arrhythmia or received treatment with antiarrythmic drug .
- severe bradycardia (HR < 45 bpm) and AV block
- pathologic esophageal lesion (esophageal stricture or varix )
- pregnancy
- psychiatric/central nervous system disturbance that would preclude completion of the QoR-40 questionnaire
- History of alcohol or drug abuse
Trial design
111 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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