Effects of Dextrose on Knee Osteoarthritis

Taipei Medical University

Status and phase: Unknown; Phase 4

Conditions: Functional Disturbance; Physical Activity

Treatments: Device: hyaluronic acid; Drug: dextrose

Study type: Interventional

Funder types: Other

Identifiers

NCT03238183

MOST 106-2314-B-341-003

Details and patient eligibility

About

Using double blind, randomized controlled design to study the immediate, short-term and intermediate-term therapeutic effects of ultrasound guided hyaluronic acid injection and hyaluronic acid combined dextrose injection to patients with knee osteoarthritis.

Full description

A total of 106 patients will be collected. The participants will be randomized into two groups, including hyaluronic acid group and hyaluronic acid combined dextrose group.

The hyaluronic acid group will receive 3 times of hyaluronic acid injection per week in three weeks; the hyaluronic acid combined dextrose group will receive 3 times of hyaluronic acid combined dextrose injection per week in three weeks.

The pain, physical activity, and functional performance will be evaluated.

All the evaluations will be re-evaluated at one week after injection, one month after injection, three months after injection, and six month after injection.

Subjects and the evaluator will be both blinded to the group's classification during the whole course of study.

Enrollment: 106 estimated patients

Sex: All

Ages: 40 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• knee osteoarthritis with Kellgren/Lawrence grade II or III

Exclusion criteria

• who have neurological deficit, such as stroke who have implant in knee

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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106 participants in 2 patient groups, including a placebo group

hyaluronic acid combined dextrose group

Active Comparator group

Description:

Hyaluronic acid (2 cc) combined 25% dextrose (3.5 cc 50% dextrose plus 3.5 cc 2% lidocaine) injection: one injection per week, for 3 weeks, to compare the additional therapeutic effects of combined hyaluronic acid and dextrose injections to hyaluronic acid injections

Treatment:

Drug: dextrose

Device: hyaluronic acid

hyaluronic acid group

Placebo Comparator group

Description:

Hyaluronic acid (2 cc) combined normal saline (3.5 cc normal saline plus 3.5 cc 2% lidocaine) injection: one injection per week, for 3 weeks, to compare the additional therapeutic effects of combined hyaluronic acid and dextrose injections to hyaluronic acid injections

Treatment:

Device: hyaluronic acid