Effects of DHA on Post-operative Fibrosis of Trabulectomy Blebs in Glaucoma Surgery

University Hospital Center (CHU) Dijon Bourgogne

Status: Unknown

Conditions: Deep Sclerectomy; Trabulectomy

Treatments: Procedure: Samples of fibroblasts from Tenon's capsule

Study type: Observational

Funder types: Other

Identifiers

NCT03289806

DELAZZER 2016

Details and patient eligibility

About

Post-operative fibrosis of trabulectomy blebs is a major cause of surgical failure leading to a renewed increase in intraocular pressure. The use of anti-metabolites over many years has made it possible to improve success rates for this surgery but these drugs have numerous adverse effects as they are toxic. Alternative therapies are thus necessary, and we believe that DHA could have antifibrotic effects on fibroblasts and could thus improve success rates in this surgery.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing trabulectomy or deep sclerectomy
• Patients informed about the study

Exclusion criteria

• Patients who refuse to take part in the study

Trial design

20 participants in 2 patient groups

Cases

Description:

Glaucoma surgery

Treatment:

Procedure: Samples of fibroblasts from Tenon's capsule

Controls

Description:

Strabismus surgery

Treatment:

Procedure: Samples of fibroblasts from Tenon's capsule