Effects of Dietary Fibre on Glucose Metabolism and Satiety

Lund University

Status and phase: Completed; Early Phase 1

Conditions: Obesity; Metabolic Syndrome

Treatments: Other: No priming; Other: Reference; Other: Priming; Other: Test meal

Study type: Interventional

Funder types: Other

Identifiers

NCT02093481

Dnr2013/241

Details and patient eligibility

About

The experimental model is a semi-acute study where the purpose of the study is to evaluate food factors related to colonially derived regulation of glucose metabolism (and related parameters) and satiety in healthy subjects.

Enrollment: 19 patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal fasting blood glucose, BMI 19-25 kg/m2

Exclusion criteria

• Gastrointestinal diseases or food allergies e.g. lactose-, gluten intolerance, metabolic disorders e.g. diabetes, tobacco/snuff users. Antibiotic or probiotic usage within two weeks, and during study. Vegetarians.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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19 participants in 4 patient groups

+ ind. CHO + prim

Experimental group

Description:

Test meal: ate intrinsic indigestible carbohydrates 3 days prior to measurements of variables (priming)

Treatment:

Other: Priming

Other: Test meal

- ind. CHO + prim

Experimental group

Description:

Reference:ate no intrinsic indigestible carbohydrates 3 days prior to measurements of variables (priming)

Treatment:

Other: Priming

Other: Reference

+ ind. CHO - prim

Experimental group

Description:

Test meal: ate intrinsic indigestible carbohydrates 1 day prior to measurements of variables (no priming)

Treatment:

Other: No priming

Other: Test meal

- ind. CHO - prim

Experimental group

Description:

Reference: ate no indigestible carbohydrates the day prior to measurements of variables (no priming).

Treatment:

Other: No priming

Other: Reference