Effects of Dietary Nitrate Intake on Cardiovascular Performance in Response to Hand Grip Test in Bodybuilders

University of Sao Paulo

Status: Completed

Conditions: Cardiovascular Abnormalities; Steroid Abuse

Treatments: Dietary Supplement: Beetroot juice rich in nitrate; Dietary Supplement: Beetroot juice depleted in nitrate

Study type: Interventional

Funder types: Other

Identifiers

NCT05835401

BodyBeet

Details and patient eligibility

About

Through a randomized, crossover, double-blind, placebo-controlled clinical trial, 20 bodybuilders will participate a acute-day trial with two intervention protocols: 1) placebo and 2) nitrate; in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval.

Enrollment: 13 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Anabolic steroid use in the past or actually;
• Participation at least one bodybuilding competition;

Exclusion criteria

• Previous history of acute myocardial infarction and/or stroke;
• Allergy or intolerance to nitrate, gluten, or milk;
• Medications (proton pump inhibitors, beta-blockers, calcium channels antagonists).

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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13 participants in 2 patient groups, including a placebo group

Experimental (Beetroot juice NO3)

Experimental group

Description:

Acute ingestion of beetroot juice rich in NO3 (800mg).

Treatment:

Dietary Supplement: Beetroot juice rich in nitrate

Placebo (Beetroot juice without NO3)

Placebo Comparator group

Description:

Acute ingestion of beetroot juice rich depleted in NO3.

Treatment:

Dietary Supplement: Beetroot juice depleted in nitrate