Effects of Dietary Nutrients on Liver and Adipose Tissue Metabolism

University of Oxford

Status

Unknown

Conditions

Nutrient; Excess

NAFLD

Treatments

Other: Overconsumption of specific dietary nutrient

Study type

Interventional

Funder types

Other

Identifiers

NCT03090347

Oxlip-2017-BBSRC/BHF

Details and patient eligibility

About

In health,adipose tissue stores fat from the diet. If the fat tissue stops storing dietary fat then this increases the chance of it being stored in the liver, which is related to increased risk of heart disease and type 2 diabetes. It has been suggested that having a diet high in sugars or certain fats, may cause the fat tissue and liver to change how they function; we would like to investigate this in detail.

Full description

This research aims to investigate how the overconsumption of specific macronutrients may effect adipose tissue and liver metabolism and function. Liver and heart fat content and adipose tissue and liver metabolism fasting and postprandial lipid metabolism will be assessed before and after the specific dietary intervention.

Enrollment

100 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Participant is willing and able to give informed consent for participation in the study.
Male or Female, aged ≥18 or ≤65 years.
Body Mass Index ≥19 ≤35 kg/m2
No medical condition or relevant drug therapy known to affect liver or adipose tissue metabolism.
Weight stable for the previous 3 months

Exclusion criteria

Patient is unwilling or unable to give informed consent for participation in the study
A blood haemoglobin <135mg/dL for men and <120mg/dL for women
Donated (or lost) ≥250 ml of blood in the previous two months.
On a weight loss diet or have decreased their body weight by >5% in the previous 3 months.
Have increased their body weight by >5% in the previous 3 months.
Any metabolic condition or relevant drug therapy
Current smoker
History of alcoholism or a greater than recommended alcohol intake (>30 g of alcohol daily for men and >20 g of alcohol daily for women)
Haemorrhagic disorders
Anticoagulant treatment
History of albumin allergy
Pregnant or nursing mothers
Women who are taking any contraceptive agent or device including oral contraceptives, hormone replacement therapy (HRT) or who have used these within the last 12 months
History of severe claustrophobia
Presence of metallic implants, pacemaker, or are unwilling to remove any piercings
History of an eating disorder or any other psychological condition that may affect the participants ability to adhere to study intervention/experimental diets.