Dietary Wild Blueberries and Joint Health

Nevada System of Higher Education (NSHE)

Status: Not yet enrolling

Conditions: Pain Assessment; Gut -microbiota; Inflammation Biomarkers; Joint Pain

Treatments: Dietary Supplement: Wild blueberry; Dietary Supplement: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT06828159

OMRF WB01

WBANA01 (Other Grant/Funding Number)

Details and patient eligibility

About

The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.

Enrollment: 50 estimated patients

Sex: All

Ages: 40 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults with documented multi-joint/knee arthritis

Exclusion criteria

• inability to give informed consent
• pregnancy or lactation
• planned knee replacement surgery
• allergy or contraindication to berries
• recent trauma of the knee responsible of the symptomatic knee
• intra-articular injection in the target knee/hip in the last 3 months
• oral corticosteroid therapy ≥ 5 mg/day (prednisone equivalent) at baseline
• use of berry extracts in the last 3 months
• special diets
• cancer treatment
• bone diseases

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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50 participants in 2 patient groups, including a placebo group

Wild blueberries

Experimental group

Description:

25g freeze-dried wild blueberries daily for 12 weeks

Treatment:

Dietary Supplement: Wild blueberry

Placebo

Placebo Comparator group

Description:

Placebo powder free from polyphenols matched for calories

Treatment:

Dietary Supplement: Placebo