ClinicalTrials.Veeva

Menu

Effects of Different Anesthetic Gases on Hemodynamics, Arterial Oxygenation and Lung Mechanics

S

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

Status

Completed

Conditions

Spinal Surgery
Oxygenation

Study type

Observational

Funder types

Other

Identifiers

NCT06118489
HamidiyeKAEK-98172

Details and patient eligibility

About

The bronchodilator effects of volatile anesthetics have been the subject of many clinical studies. It is known that all volatile anesthetics, especially halothane, have similar effects. Sevoflurane has been shown to reduce airway resistance more than halothane and isoflurane. Desflurane is difficult to use as an induction agent due to its harsh and extremely pungent odor and airway irritating effect. However, it has been shown that the risk of cough, respiratory arrest and laryngospasm is no different from sevoflurane when administered after intravenous induction. Although it irritates the airway, it is thought to have a bronchodilation effect as it stimulates the sympathetic system.

In spinal surgeries, prone position is required to access the operating field. When the patient is placed in the prone position, pulmonary physiology are affected. In the prone position, V/Q mismatch decreases and arterial oxygenation increases. However, lung compliance decreases and the peak inspiratory pressure required to reach the required tidal volume increases. The main purpose of this study is the effect of volatile agents on lung mechanics and oxygenisation in the prone position.

Enrollment

50 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 18-65 years old
  • ASA1-2
  • Patients planned to undergo spinal surgery

Exclusion criteria

  • 1 - Lung disease
  • BMI 35 and above
  • Smokers
  • Those under the age of 18 and over the age of 65
  • Hepatorenal disease
  • Reynaud's disease
  • Burger disease
  • Hypotensive patient
  • Neuromuscular disease
  • Those who have had thoracic surgery before
  • Those with bad Allen test results

Trial design

50 participants in 2 patient groups

sevoflurane
desflurane

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems