Effects of Different Concentrations of Pressurized-heparin Flushing Fluid on Coagulation and Platelet Function Monitored by the Sonoclot Analyzer

Yangzhou University

Status: Completed

Conditions: Heparin; Perioperative

Treatments: Drug: normal saline; Drug: Heparin

Study type: Interventional

Funder types: Other

Identifiers

NCT04355273

20200420

Details and patient eligibility

About

Heparin diluent or normal saline is generally used as the arterial tube flushing in clinical practice, but there is no consensus on the choice of flushing fluid. Heparin can affect the blood coagulation function, and even lead to heparin-related thrombocytopenia, increasing the risk of perioperative embolism. Sonoclot is a blood viscoelasticity test, which can provide comprehensive information on the coagulation's cascade and the entire process and be quicker and more effective than routine laboratory coagulation tests. In this research, the coagulation and platelet function analyzer called Sonoclot is used to evaluate the effect of different concentrations of pressurized heparin on the coagulation and platelet function of perioperative patients, which can provide a reference for the clinical choice of appropriate arterial flushing.

Enrollment: 60 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of gastrointestinal cancer
• Ages ranged from 18 to 75
• ASA I~III

Exclusion criteria

• Pregnancy
• modified Allen Test negative
• history of taking anti-platelet drugs such as aspirin one week before surgery, heparin allergy and thrombotherapy
• two failed catheterizations of the same artery
• significant diseases in liver and kidney function
• refusal of patients

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 3 patient groups, including a placebo group

Heparin with a concentration of 2 U/ml

Experimental group

Description:

heparin dilution is placed in a pressure bag with a pressure of 300 mmHg

Treatment:

Drug: Heparin

Drug: Heparin

Heparin with a concentration of 4 U/ml

Experimental group

Description:

heparin dilution is placed in a pressure bag with a pressure of 300 mmHg

Treatment:

Drug: Heparin

Drug: Heparin

normal saline

Placebo Comparator group

Description:

normal saline is placed in a pressure bag with a pressure of 300 mmHg

Treatment:

Drug: normal saline