Effects of Different Deflation Methods on Coughing Response and Hemodynamics During Extubation

Zhuan Zhang

Status: Enrolling

Conditions: Deflating Method

Treatments: Behavioral: Tracheal tube cuffs differ in deflation

Study type: Interventional

Funder types: Other

Identifiers

NCT05647395

20221121

Details and patient eligibility

About

Patients with endotracheal intubation and general anesthesia often have severe choking and hemodynamic fluctuations during the extubation period, which increases the risk of cerebrovascular accident, arrhythmia, incision bleeding and so on . This study aimed to observe the effects of different methods of deflating of endotracheal tube cuffs on cough response and hemodynamics during periextubation in patients undergoing general anesthesia surgery.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Elective endotracheal intubation under general anesthesia.
2. Operation time < 3 h.
3. ASA grade I or II.
4. Age 18~65 years old.

Exclusion criteria

1. Throat and neck surgery.
2. Those assessed to have a high risk of reflux aspiration.
3. Difficulty intubation.
4. History of snoring before surgery.
5. Recent respiratory illness such as chronic cough.
6. Previous airway hyperresponsiveness, such as asthma.
7. recent use of cough suppressants.
8. Patients with severe heart, liver and kidney diseases.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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90 participants in 2 patient groups

Slowly and evenly draw the gas in the cuff

Experimental group

Treatment:

Behavioral: Tracheal tube cuffs differ in deflation

One-time aspiration of tracheal catheter cuff gas

No Intervention group