Effects of Different Doses of Dexmedetomidine on Fentanyl-induced Cough

Yangzhou University

Status and phase: Unknown; Phase 1

Conditions: Fentanyl-induced Cough

Treatments: Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT03126422

20170413

Details and patient eligibility

About

The investigators aimed to investigate the effects of pretreatment with different doses of dexmedetomidine on the cough caused by fentanyl during anesthetic induction.

Patients undergoing elective surgeries under general anesthesia will be randomly allocated to 4 groups (n = 60, each group). Dexmedetomidine 0, 0.03, 0.06, and 0.09 μg/kg/min will be pump-administered in 10 mins to groups I, II, III, and IV, respectively, followed by the induction of general anesthesia with intravenous fentanyl 4 μg/kg. The incidences and severity of cough that occurred within 2 min after the injection of fentanyl will be recorded, and the incidences of cardiovascular adverse events that occurred between the administration of the dexmedetomidine infusion and 2 min after tracheal intubation will be recorded.

Enrollment: 240 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients undergoing elective surgeries under general anesthesia.

Exclusion criteria

• Patients with contraindications of dexmedetomidine.
• Patients younger than 18 years old and older than 65 years old.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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240 participants in 4 patient groups

Dexmedetomidine 0 μg/kg/min

Experimental group

Treatment:

Drug: Dexmedetomidine

Dexmedetomidine 0.03 μg/kg/min

Experimental group

Treatment:

Drug: Dexmedetomidine

Dexmedetomidine 0.06 μg/kg/min

Experimental group

Treatment:

Drug: Dexmedetomidine

Dexmedetomidine 0.09 μg/kg/min

Experimental group

Treatment:

Drug: Dexmedetomidine