Effects of Different Exercise Training Modalities in Alpha-1 Antitrypsin Deficiency Patients

Schön Klinik Berchtesgadener Land

Status: Unknown

Conditions: Chronic Obstructive Pulmonary Disease; Alpha 1-Antitrypsin Deficiency

Treatments: Procedure: Exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT03802357

AAT Training

Details and patient eligibility

About

Pulmonary rehabilitation (PR) including exercise training is highly effective by improving health-related quality of life, exercise capacity and symptoms in patients with chronic obstructive pulmonary disease (COPD). Therefore, PR is a main component in the management of COPD. In a former study patients with Alpha-1 Antitrypsin deficiency (A1ATD)-related COPD (genotype PiZZ) have been found to show smaller improvements in exercise capacity after a 3-week inpatient PR program compared to COPD patients without A1ATD (genotype PiMM)[1]. These between-group differences were mirrored by missing adaptations of the fatigue-resistant skeletal muscle fibre type I in A1ATD patients. This was in contrast to COPD patients without A1ATD who increased the proportion of this fibre type after PR. Myofibre type I is crucial because it enables patients for physical endurance activities (walking, cycling etc.) during their daily life.

The aim of this study is to compare the effects of an exercise Training program with high vs. moderate Training intensity in order to find a Training modality which improves Training effects in A1ATD patients.

Enrollment: 30 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COPD patients with A1ATD (genotype PiZZ)
• COPD patients without A1ATD (genotype PiMM)
• Global initiative for chronic obstructive lung disease (GOLD) stage III-IV
• Medical Treatment according to recent A1ATD guidelines

Exclusion criteria

• General exclusion criteria for physical Training such as acute coronary Syndrome, acute myo- or pericarditis, acute lung embolism, acute heart failure, orthopedic comorbidities which prevent patients from participating in exercise Training program.
• No written informed consent
• Non-compliance

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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30 participants in 2 patient groups

High training intensity

Experimental group

Description:

Exercise Training with high intensities consists of a cycling Interval Training at 100% of the individual Peak work rate, resistance Training for 3 sets à 8 repetitions and squats on a Vibration plate.

Treatment:

Procedure: Exercise training

moderate training intensity

Active Comparator group

Description:

Exercise Training with moderate intensities consists of a cycling endurance Training at 60% of the individual Peak work rate, resistance Training for 3 sets à 20 repetitions and squats on the floor.

Treatment:

Procedure: Exercise training