Effects of Different I:E Ratio on Intrapulmonary Shunt Fraction and Oxygenation During One Lung Ventilation in the Lateral Decubitus Position

Yonsei University

Status: Completed

Conditions: Lung Lobectomy; Lung Cancer

Treatments: Procedure: I:E ratio

Study type: Interventional

Funder types: Other

Identifiers

NCT01499212

1-2011-0058

Details and patient eligibility

About

The purpose of this study is to investigate effect of increasing inspiratory time (I:E ratio 1:1) on intrapulmonary shunt fraction and oxygenation during one lung ventilation in the lateral decubitus position.

Full description

Increasing inspiratory time(e.g. Inverse ratio ventilation) has been known that had advantage of alveolar recruitment, preventing of ateletasis. On the contrary, it has disadvantange of intrinsic PEEP, air trapping. There is few study on one lung ventilation in lateral decubitus position about this ventilation method. We were going to investigate effecf of this ventilation method.

Enrollment: 58 patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA physical status class I, II
• Use of Double lumen tube
• Unilateral lung lobectomy

Exclusion criteria

• COPD
• CAOD
• Unstable hemodynamic status
• Peak airway pressure > 30mmHg (Two lung ventilation)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Quadruple Blind

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58 participants in 1 patient group

I:E ratio 1:1

Experimental group

Treatment:

Procedure: I:E ratio