Effects of Different Kinds, Different Doses of 5-HT3 Receptor Antagonists on Prevention of Hypotension

Seoul National University

Status: Unknown

Conditions: Hypotension; Nausea and Vomiting; Vasopressor; Shivering

Treatments: Drug: ramosetron; Drug: ondansetron; Drug: placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT01669213

WSAhn_ramosetron_hypotension

Details and patient eligibility

About

The purpose of this study is to estimate effects of different kinds, different dose of 5-HT3 receptor antagonists on prevention of hypotension after spinal anesthesia

Enrollment: 100 estimated patients

Sex: All

Ages: 20 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing spinal anesthesia

Exclusion criteria

• hypersensitivity on 5-HT3 receptor antagonists hypertension cardiovascular disease intake of selective serotonin reuptake inhibitor

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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100 participants in 4 patient groups, including a placebo group

ramosetron 0.3 mg

Active Comparator group

Description:

preparation of ramosetron 0.3 mg

Treatment:

Drug: ramosetron

ondansetron 8 mg

Active Comparator group

Description:

preparation of ondansetron 8mg

Treatment:

Drug: ondansetron

Drug: ondansetron

ondansetron 4 mg

Active Comparator group

Description:

preparation of ondansetron 4mg

Treatment:

Drug: ondansetron

Drug: ondansetron

non 5-HT3 receptor antagonist

Placebo Comparator group

Description:

preparation of normal saline 5 ml

Treatment:

Drug: placebo