Effects of Different Polyphenol-containing Beverages on the Immune System and on Muscular Growth Factors

Balgrist University Hospital

Status: Completed

Conditions: Food Sensitivity

Treatments: Other: non-alcoholic Pilsner; Other: non-alcoholic wheat beer; Other: apple spritzer; Other: lemonade

Study type: Interventional

Funder types: Other

Identifiers

NCT04983420

Polyphenol

Details and patient eligibility

About

In this research project, the effect of different polyphenol-containing beverages with varying alcohol content of < 0.4 vol% on immune function as well as muscular growth factors will be investigated

Enrollment: 20 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy
• Age 20 - 60 years
• Written informed consent

Exclusion criteria

• severe gastrointestinal disease or known malabsorption
• use of proton pump inhibitors
• malignancies
• rheumatoid diseases
• metabolic syndrome
• acute or chronic infections or inflammatory diseases
• use of medications or supplements to interfere with immune function
• alcohol and/or drug abuse or addiction
• dependent relationship with the project manager or his or her employees
• pregnancy or breastfeeding
• chronic illness or regular use of medication (except hormonal contraception)
• smoker

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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20 participants in 4 patient groups, including a placebo group

non-alcoholic Pilsner

Experimental group

Description:

1 L non-alcoholic Pilsner per day for 2 weeks

Treatment:

Other: non-alcoholic Pilsner

non-alcoholic wheat beer

Experimental group

Description:

1 L non-alcoholic wheat beer per day for 2 weeks

Treatment:

Other: non-alcoholic wheat beer

apple spritzer

Active Comparator group

Description:

1 L apple spritzer per day for 2 weeks

Treatment:

Other: apple spritzer

lemonade

Placebo Comparator group

Description:

1 L lemonade per day for 2 weeks

Treatment:

Other: lemonade