Effects of Different Revascularization StrateGies in Complex Coronary Artery DiseasE (EDGE)

Capital Medical University

Status: Unknown

Conditions: Coronary Artery Disease

Treatments: Procedure: The procedures include PCI, CABG and HCR

Study type: Observational

Funder types: Other

Identifiers

NCT05121610

EDGE

Details and patient eligibility

About

Coronary heart disease is one of the most serious diseases that endanger people's health. Complex coronary artery disease is critical and has high mortality. Therefore, it is urgent to explore the best treatment method for complex coronary artery disease. Some previous studies have shown that patients with left main coronary artery disease with a SYNTAX score> 32 points, and diabetic/non-diabetic three-vessel disease patients with coronary heart disease with a SYNTAX score > 22 points, CABG is recommended for revascularization. However, with the continuous innovation of surgical technology and the rapid development of surgical instruments, the treatment of patients with complex coronary artery disease is increasing. Therefore, it is necessary to investigate the effects of different revascularization strategies on long-term prognosis in patients with complex coronary artery disease (SYNTAX score > 22 points).

Enrollment: 2,864 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Male/female aged 18-80 years;
2. Having complex coronary artery disease (SYNTAX score > 22 points) undergoing myocardial revascularization

Exclusion criteria

1. Cardiogenic shock or hemodynamic instability;
2. Undergoing other heart surgery at the same time;
3. Previous coronary artery bypass surgery;
4. History of cerebral hemorrhage;
5. Ischemic stroke in the past six months;
6. History of cancer;
7. Life expectancy no more than 12 months

Trial design

2,864 participants in 3 patient groups

CABG group

Description:

CABG group

Treatment:

Procedure: The procedures include PCI, CABG and HCR

HCR group

Description:

HCR group

Treatment:

Procedure: The procedures include PCI, CABG and HCR

PCI group

Description:

PCI group

Treatment:

Procedure: The procedures include PCI, CABG and HCR