Effects of Different Types of Anesthesia on Stress Response in Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus

Guangzhou General Hospital of Guangzhou Military Command

Status: Unknown

Conditions: Diabetes; Anesthesia; Stress

Treatments: Other: different types of anesthesia; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT01963546

WQie

Details and patient eligibility

About

General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Explore the effect of three kinds of anesthesia,that is the total intravenous anesthesia, inhalation anesthesia and inhalation and intravenous anesthesia on stress reactions generated by patients with diabetes conducted gastric - bypass surgery , and choose a best way from three kinds of anesthesia to control stress reaction of diabetics. After selecting the appropriate anesthesia method, assess the effect of dexmedetomidine on controlling stress response from diabetics undergoing laparoscopic gastric-bypass surgical.

Full description

Research content and indicators

1. Preparation of serum: 3ml of blood were taken before induction of anesthesia (after entering the operating room), surgery began 1h, surgery began 2h, 24h after surgery, and placed at dry tube, centrifuged for 10min at 3000g after placing at room temperature for 2h , the resulting supernatant was subpassaged in tube, stored at -20℃ until analysis.
2. Indicators to detect in serum contained Tumor Necrosis Factor-α, Interleukin-6, Interleukin-10, plasma glucose, cortisol,insulin and c-peptide.
3. Record the vital signs.

Enrollment: 80 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists（ASA）Ⅰ ~ Ⅱpatients
• Type 2 Diabetes Mellitus patient undergoing Laparoscopic Gastric Bypass surgery
• between 18 and 60 years of age

Exclusion criteria

• A history of cardiopulmonary disease, liver and kidney dysfunction, abnormal coagulation
• Thyroid disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 4 patient groups

Intravenous anesthesia

Other group

Description:

We use total intravenous anesthesia to assess the stress response.

Treatment:

Other: different types of anesthesia

Intravenous and Inhalation anesthesia

Other group

Description:

We use intravenous and inhalation anesthesia during the surgery.

Treatment:

Other: different types of anesthesia

Inhalation anesthesia

Other group

Description:

We use inhalation anesthesia during the surgery.

Treatment:

Other: different types of anesthesia

Dexmedetomidine

Experimental group

Description:

the effect of dexmedetomidine on the stress responses generated by patients with diabetic given gastric-bypass surgery : Group A group given the best anesthetic technique from preliminary work + dexmedetomidine Dexmedetomidine as a inducer was given intravenous infusion loading dose 1.0μg/kg for 10min, maintained intravenous infusion by 0.4μg/kg/h. Group B group given the best anesthesia method from preliminary work(not using dexmedetomidine).

Treatment:

Drug: Dexmedetomidine