Effects of Different Ventilatory Strategy on Intraoperative Atelectasis During Bronchoscopy Under General Anesthesia.

Guangzhou Institute of Respiratory Disease

Status: Not yet enrolling

Conditions: Lung Disorder

Treatments: Procedure: conventional mechanical ventilation; Procedure: VESPA

Study type: Interventional

Funder types: Other

Identifiers

NCT05720845

20230111

Details and patient eligibility

About

This trial compares two different types of ventilation for the prevention of partial or complete collapsed lung (atelectasis) in patients undergoing interventional pulmonology procedures under general anesthesia. Ventilatory strategy to prevent reduce the intra-procedural development of atelectasis during interventional pulmonology procedures under general anesthesia.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients undergoing interventional pulmonology procedures with radial probe endobronchial ultrasound (RP-EBUS) for peripheral lung lesions
• Recent (< 4 weeks) chest computed tomography (CT) performed prior to the bronchoscopy

Exclusion criteria

• Patients with baseline lung consolidation, interstitial changes or lung masses (> 3 cm in diameter) in dependent areas of the lung (right/left [R/L] B6, 9, or 10 bronchial segments) as seen on most recent CT
• History of primary or secondary spontaneous pneumothorax

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

conventional mechanical ventilation

Active Comparator group

Description:

Conventional mechanical ventilation for General Anesthesia

Treatment:

Procedure: conventional mechanical ventilation

VESPA

Experimental group

Description:

ventilatory strategy to prevent atelectasis for General Anesthesia

Treatment:

Procedure: VESPA