Effects of Disrupting Prolonged Sitting With Different Physical Activity Protocols on Metabolic Risk Factors in Sedentary Adults

Rigshospitalet

Status: Unknown

Conditions: Breaking Prolonged Sitting With Physical Activity; Prolonged Sitting

Treatments: Behavioral: Breaking prolonged sitting with physical activity

Study type: Interventional

Funder types: Other

Identifiers

NCT02215603

ProlongedSitting

Details and patient eligibility

About

Great controversy exists with respect to the optimal or the minimum volume, intensity, and frequency of physical activity capable of attenuating the hazards of prolonged sitting on the metabolic profile. Thus, our study aims to comprehensively investigate the effects of disrupting prolonged sitting with different physical activity protocols on metabolic risk factors in sedentary males.

Ten sedentary males will take part in this randomized cross-over trial consisting of four 27-h conditions. All conditions will be identical except for the physical activity: prolonged sitting intervention (SIT) participants will sit continuously for 9 hours; prolonged sitting+interval standing intervention (STAND), participants will stand for 15 min every 30 minutes (total 270 min) during the 9 hours of sitting; prolonged sitting+moderate-intensity exercise bout (MVPA) participants will perform a 30-min moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they will sit for the remaining time; and prolonged sitting+moderate-intensity exercise bout +interval standing intervention (MVPA-STAND), participants will perform a 30-min moderate-intensity exercise bout on a treadmill (energy-matched to STAND), after which they will stand for 15 min every 30 minutes (total 240 min) during the remaining 8 hours of sitting. Blood glucose, insulin, lipids and cytokines will be determined.

The investigators expect that disrupting prolonged sitting with intermittent standing and a moderate-exercise bout will positively affect the metabolic profile of the participants. Furthermore, we will investigate if combined, these strategies will have an additive effect.

Enrollment: 10 estimated patients

Sex: Male

Ages: 25 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Males,
• age 25-55 y,
• BMI >18 and <35 kg/m2

Exclusion criteria

• Clinically diagnosed diabetes,
• dyslipidaemia,
• hypertension,
• use of glucose- and/or lipid-lowering medication,
• smoking,
• evidence of thyroid, liver, lung, heart or kidney disease,
• non-sedentary occupation and primary means of commuting to work (i.e., cycling) in the last 4 months,
• VO2max levels above the considered average fitness according to age,
• contraindication to increased levels of physical activity.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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10 participants in 4 patient groups

Prolonged sitting

No Intervention group

Description:

9 h of prolonged sitting

Prolonged sitting + interval standing bouts

Experimental group

Description:

Stand bout for 15-min every 30 minutes during the 9 hours of sitting

Treatment:

Behavioral: Breaking prolonged sitting with physical activity

Moderate exercise bout + Prolonged sitting

Experimental group

Description:

30-min moderate-intensity exercise bout followed by 8 h of sitting

Treatment:

Behavioral: Breaking prolonged sitting with physical activity

Moderate exercise bout + Prolonged sitting +Standing bouts

Experimental group

Description:

30-min moderate-intensity exercise bout and stand bout for 15-min every 30 minutes during the remaining 8 hours of sitting

Treatment:

Behavioral: Breaking prolonged sitting with physical activity