Effects of e-Cigarettes on Perceptions and Behavior - Substudy 1

University of Southern California

Status: Completed

Conditions: Cigarette Smoking; Electronic Cigarette Use; Vaping; Cigarette Use, Electronic

Treatments: Drug: E-cigarette e-liquid

Study type: Interventional

Funder types: Other

Identifiers

NCT04399031

HS-18-00839 Substudy 1

Details and patient eligibility

About

This project will assess the ways in which e-cigarette product diversity impacts the user experience to inform potential regulations by identifying product characteristics that may: (1) put young adults at risk for tobacco product use; and (2) facilitate adult smokers switching to e-cigarettes. There are three primary objectives to the study: (1) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect product appeal across young adult e-cigarette users and middle-age/older adult smokers; (2) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect abuse liability in young adult e-cigarette users and the ability to resist smoking in adult smokers; (3) Determine the affect of product characteristics on e-cigarette nicotine delivery profile. For this substudy, young adult vapers (N=100) and adult smokers (N=100) will attend one laboratory session in which they will self-administer e-cigarette products varied according to within-subject e-cigarette factors (e.g., flavor, nicotine formulation).

Enrollment: 124 patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Vapers/E-cigarette Users

• E-cigarette/vaping device use at least three days per week for at least 2 months
• Regular use of e-cigarettes/vaping devices containing nicotine

Cigarette Smokers

• Daily cigarette smoking for at least two years
• Currently smoke at least four cigarettes per day
• Interested in trying an e-cigarette or current use of an e-cigarette

Exclusion criteria

Vapers/E-cigarette Users

• Pregnant or breastfeeding
• Desire to cut down on use of e-cigarette/vaping device

Cigarette Smokers

• Pregnant or breastfeeding
• Current daily use of other combustible tobacco products (such as cigars)

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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124 participants in 20 patient groups

E-cigarette e-liquid 1

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 2

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 3

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 4

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 5

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 6

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 7

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 8

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 9

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 10

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 11

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 12

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 13

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 14

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 15

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 16

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 17

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 18

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 19

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid

E-cigarette e-liquid 20

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Drug: E-cigarette e-liquid