Effects of e-Cigarettes on Perceptions and Behavior - Substudy 2

University of Southern California

Status: Completed

Conditions: Cigarette Smoking; Electronic Cigarette Use; E-Cig Use; Cigarette Use, Electronic

Treatments: Other: E-cigarette e-liquid self-administration

Study type: Interventional

Funder types: Other

Identifiers

NCT05958966

HS-18-00839 Substudy 2

Details and patient eligibility

About

This project will assess the ways in which e-cigarette product diversity impacts the user experience to inform potential regulations by identifying product characteristics that may: (1) put young adults at risk for tobacco product use; and (2) facilitate adult smokers switching to e-cigarettes. There are three primary objectives to the study: (1) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect product appeal across young adult e-cigarette users and middle-age/older adult smokers; (2) Determine which dimensions of e-cigarette product diversity differentially affect product appeal in the overall population of tobacco product users as well as affect abuse liability in young adult e-cigarette users and the ability to resist smoking in adult smokers; (3) Determine the affect of product characteristics on e-cigarette nicotine delivery profile. For this substudy, adult smokers (N=200) will attend two laboratory session in which they will self-administer e-cigarette products varied according to within-subject e-cigarette factors (e.g., flavor, nicotine formulation) and smoke their own cigarettes.

Enrollment: 73 patients

Sex: All

Ages: 21+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Regular use of cigarettes containing nicotine.

Exclusion criteria

• Pregnant or planning to become pregnant.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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73 participants in 5 patient groups

E-cigarette e-liquid 1

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Other: E-cigarette e-liquid self-administration

E-cigarette e-liquid 2

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Other: E-cigarette e-liquid self-administration

E-cigarette e-liquid 3

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Other: E-cigarette e-liquid self-administration

E-cigarette e-liquid 4

Experimental group

Description:

Participants will self-administer an e-cigarette e-liquid.

Treatment:

Other: E-cigarette e-liquid self-administration

No e-liquid

No Intervention group

Description:

Participants do not receive an e-cigarette e-liquid to self-administer.