Effects of Endoscopic Lung Volume Reduction on Diaphragm Function and Conformation

Free University of Brussels (ULB)

Status: Completed

Conditions: COPD

Treatments: Device: Endoscopic lung volume reduction

Study type: Interventional

Funder types: Other

Identifiers

NCT05799352

P2018/227

Details and patient eligibility

About

Chronic obstructive lung disease (COPD) is a common disease that is frequently complicated by hyperinflation. The resulting increase in lung volume impairs the diaphragmatic function because of a shortening of the diaphragmatic fibers and an increase in the radius of curvature of the diaphragmatic domes. Lung volume reduction surgery (LVRS) has already shown an improvement in diaphragmatic function that could be explained by a change of the diaphragm conformation. More recently, endoscopic lung volume reduction (ELVR) has shown benefits in terms of respiratory function, exercise capacity and quality of life, but the mechanisms of these improvements are poorly understood. Therefore, we aim to evaluate the evolution of the diaphragmatic function and the changes in diaphragmatic conformation after unilateral ELVR.

Enrollment: 35 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• valves insertion

Exclusion criteria

• TLVR < 50 %

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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35 participants in 1 patient group

Endoscopic lung volume reduction

Experimental group

Description:

All the patients will have endobronchial valves insertion. We will evaluate before and 3 months after the evolution of the diaphragmatic strength and conformation.

Treatment:

Device: Endoscopic lung volume reduction